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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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Deep transcranial magnetic stimulation for obsessive compulsive disorder.

Alexis G McCathern1, David S Mathai1, Raymond Y Cho1

  • 1Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine , Houston, TX, USA.

Expert Review of Neurotherapeutics
|July 21, 2020
PubMed
Summary

Deep transcranial magnetic stimulation (dTMS) offers a promising, minimally invasive treatment for treatment-resistant obsessive-compulsive disorder (OCD). Further research is needed to fully establish its effectiveness and optimize its application in clinical practice.

Keywords:
OCDdtmsneurophysiologypsychiatrytreatment-resistant OCD

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Technology

Background:

  • Obsessive-compulsive disorder (OCD) is a prevalent and potentially chronic psychiatric condition.
  • Standard treatments like cognitive-behavioral therapy and serotonin uptake inhibitors are not universally effective.
  • Treatment-resistant OCD presents a significant clinical challenge, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review the current research on the efficacy of deep transcranial magnetic stimulation (dTMS) for treatment-resistant OCD.
  • To identify limitations and gaps in existing dTMS research for OCD.
  • To explore the future potential of dTMS in managing treatment-resistant OCD.

Main Methods:

  • Systematic literature review of studies investigating dTMS for treatment-resistant OCD.
  • Analysis of research methodologies, reported outcomes, and side effect profiles.
  • Synthesis of findings to evaluate the current evidence base.

Main Results:

  • dTMS is emerging as a potential alternative for individuals with treatment-resistant OCD.
  • The therapy is noted for its favorable safety profile and non-invasive nature.
  • Current research highlights variability in treatment outcomes and methodological inconsistencies.

Conclusions:

  • dTMS shows promise as an adjunctive or alternative treatment for refractory OCD.
  • Addressing research shortcomings, such as standardized protocols and larger trials, is crucial.
  • Further investigation is warranted to optimize dTMS parameters and confirm its long-term efficacy and safety in OCD treatment.