Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35-39 years: a...

Area of Science:

• Reproductive Endocrinology
• In Vitro Fertilization (IVF)
• Gynecologic Surgery

Background:

• Fallopian tube issues are a primary cause for in vitro fertilization-embryo transfer (IVF-ET).
• Salpingectomy, the removal of fallopian tubes, is common for conditions like ectopic pregnancy and hydrosalpinx.
• Female age significantly impacts ovarian reserve and IVF outcomes, including live birth rates.

Purpose of the Study:

• To investigate the influence of salpingectomy and patient age on ovarian reserve, ovarian response, and pregnancy outcomes in women undergoing IVF-ET.
• To determine if salpingectomy affects live birth rates differently across various age groups.

Main Methods:

• A retrospective study of 1922 patients undergoing IVF-ET between 2012 and 2018.
• Patients were divided into salpingectomy (n=534) and control (n=1388) groups.
• Subgroup analysis by age (<35 years and 35-39 years) to assess ovarian reserve, response, and IVF outcomes.

Main Results:

• Significantly lower antral follicle counts (AFC) were observed in the salpingectomy subgroup aged 35-39 compared to controls.
• No significant differences were found in AFC for women younger than 35.
• No significant differences were noted in FSH, LH, E2, gonadotropin dose, retrieved oocytes, fertilization, embryo availability, or live birth, clinical pregnancy, miscarriage, ectopic pregnancy, or multiple pregnancy rates between groups.

Conclusions:

• Salpingectomy may reduce antral follicle count in IVF patients aged 35-39, but does not appear to affect live birth rates.
• Advanced female age is negatively correlated with clinical pregnancy and live birth rates in IVF-ET patients.