Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleus01:32

The Nucleus

99.4K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
99.4K
The Nucleus01:25

The Nucleus

7.0K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
7.0K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

51.8K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
51.8K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.1K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.1K
DNA Packaging00:58

DNA Packaging

111.5K
Overview
111.5K
Condensins02:15

Condensins

4.3K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Analysis of Common Questions and Concerns of Older Adults with Multiple Chronic Conditions.

Journal of the American Board of Family Medicine : JABFM·2026
Same author

Active RNA synthesis patterns nuclear condensates.

Cell systems·2026
Same author

Family Physicians' Views of Who They Are Accountable To and Current Quality Metrics.

JAMA network open·2026
Same author

Density transitions in the regulation of transcription.

Molecular cell·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Protein codes and mobility together shape cellular function and disease.

Trends in biochemical sciences·2025

Related Experiment Video

Updated: Dec 14, 2025

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.2K

Biomolecular Condensates in the Nucleus.

Benjamin R Sabari1, Alessandra Dall'Agnese2, Richard A Young3

  • 1Laboratory of Nuclear Organization, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA; Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142 USA.

Trends in Biochemical Sciences
|July 21, 2020
PubMed
Summary

Nuclear processes utilize specialized compartments called condensates to organize molecules. These biomolecular condensates concentrate proteins and RNA at specific genomic locations, enabling novel cellular regulation beyond simple diffusion.

Keywords:
biomolecular condensateschromatin regulationcondensate dysregulationcondensate regulationgene regulationnuclear organization

More Related Videos

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

4.9K
Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
10:57

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Published on: November 11, 2025

601

Related Experiment Videos

Last Updated: Dec 14, 2025

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.2K
Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

4.9K
Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
10:57

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Published on: November 11, 2025

601

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genomics

Background:

  • Nuclear processes like DNA replication and transcription involve numerous protein and RNA molecules.
  • Previously, molecular localization was primarily attributed to diffusion-based interactions.
  • Emerging evidence points to the role of nuclear condensates in organizing these processes.

Purpose of the Study:

  • To describe the shared characteristics of nuclear condensates.
  • To identify components responsible for locus-specific condensate formation.
  • To elucidate the regulatory mechanisms governing these nuclear compartments.

Main Methods:

  • Review of recent studies on nuclear condensates.
  • Analysis of molecular components and their roles in condensate formation.
  • Investigation of specificity elements and regulatory mechanisms.

Main Results:

  • Nuclear processes occur within distinct condensates, not solely by diffusion.
  • These condensates compartmentalize and concentrate necessary proteins and RNA at specific genomic sites.
  • Condensates exhibit common features and emergent properties conferring regulatory capabilities.

Conclusions:

  • Nuclear condensates are crucial for efficient and regulated molecular organization within the cell.
  • Understanding condensate formation and regulation offers insights into novel cellular control mechanisms.
  • These compartments represent a significant departure from diffusion-based models of molecular localization.