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Familial Mediterranean fever: What associations to screen for?

Salem Bouomrani1,2, Ines Masmoudi1,2, Sawssan Ben Teber1,2

  • 1Sfax Faculty of Medicine, University of Sfax, Tunisia.

Reumatologia
|July 21, 2020
PubMed

Insights

Familial Mediterranean fever (FMF), a common genetic autoinflammatory disorder, is frequently linked with other autoimmune and genetic conditions. Early detection of these associations improves patient management and outcomes.

Area of Science:

  • Genetics
  • Immunology
  • Internal Medicine

Background:

  • Familial Mediterranean fever (FMF) is the most prevalent hereditary recurrent fever syndrome.
  • Genetically characterized in 1992, FMF results from MEFV gene mutations.
  • Prevalence is high in specific populations, including Sephardic Jews, Armenians, Turks, and Middle Eastern Arabs.

Purpose of the Study:

  • To review the common associations of FMF with other diseases.
  • To inform healthcare professionals about conditions frequently co-occurring with FMF.
  • To emphasize the importance of early detection for improved patient care.

Main Methods:

  • Literature review of recent publications on FMF associations.
  • Synthesis of information on autoimmune, genetic, and autoinflammatory conditions linked to FMF.
  • Focus on clinical relevance for healthcare professionals.

Main Results:

  • FMF is often associated with other autoimmune, genetic, and autoinflammatory diseases.
  • Identification of specific co-occurring conditions is crucial for comprehensive patient assessment.
  • Early recognition of these associations impacts treatment strategies.

Conclusions:

  • Healthcare professionals managing FMF patients should be aware of potential associated conditions.
  • Screening for associated diseases can lead to better patient outcomes.
  • Understanding FMF comorbidities enhances the overall management of the disorder.
Keywords:
MEFV genechronic inflammationfamilial Mediterranean feverperiodic feverpyrin

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