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Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Production of Formed Elements01:34

Production of Formed Elements

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Hemoglobin01:24

Hemoglobin

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Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
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Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Related Experiment Video

Updated: Dec 14, 2025

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells
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Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

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What does a hemogram say to us?

Tülin Tiraje Celkan1

  • 1Division of Pediatric Hematology-Oncology, Department of Pediatrics, İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, İstanbul, Turkey.

Turk Pediatri Arsivi
|July 21, 2020
PubMed
Summary

Complete blood count (CBC) is a vital blood test for diagnosing various conditions like anemia, infections, and cancers. Understanding CBC interpretation is crucial for pediatricians to effectively assess children's health.

Area of Science:

  • Hematology
  • Clinical Pathology
  • Pediatrics

Background:

  • Complete blood count (CBC) is a fundamental laboratory test.
  • CBC provides critical data on hemoglobin, white blood cells, platelets, and red blood cell indices.
  • Automated CBCs offer differential counts for white blood cell subgroups.

Purpose of the Study:

  • To elucidate key interpretation strategies for complete blood count (CBC) in pediatric care.
  • To provide guidance for differentiating normal CBC results from abnormal findings.
  • To enhance pediatricians' understanding of CBC for improved patient assessment.

Main Methods:

  • Review of standard complete blood count parameters and their clinical significance.
  • Analysis of differential white blood cell counts.
Keywords:
Abnormal hemogram valueschildhemogramnormal hemogram values

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  • Discussion of common deviations and their diagnostic implications.

    • Main Results:

    • CBC is essential for diagnosing anemia, hematological cancers, infections, and immunodeficiencies.
    • CBC aids in monitoring drug side effects.
    • Accurate CBC interpretation is vital for pediatric patient assessment.

    Conclusions:

    • A thorough understanding of CBC interpretation is essential for quality pediatric care.
    • This paper offers strategies to distinguish normal CBC results from clinically significant abnormalities.
    • Enhanced CBC interpretation skills benefit the assessment of both healthy and ill children.