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Diabetes Mellitus: Type 2 and Gestational01:22

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Related Experiment Video

Updated: Dec 14, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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TRPV2 POLYMORPHISMS INCREASE OR REDUCE THE RISK OF TYPE 2 DIABETES - HASHIMOTO THYROIDITIS COMORBIDITY.

F Bulut Arikan1, F A Özdemir2, D Şen3

  • 1Kırıkkale University, Faculty of Medicine, Dept. of Physiology, Elazig, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)
|July 21, 2020
PubMed
Summary
This summary is machine-generated.

The TRPV2 gene rs14039 GG genotype increases the risk of type 2 diabetes mellitus and Hashimoto thyroiditis. Conversely, rs4792742 polymorphisms offer a protective effect against these conditions.

Keywords:
Hashimoto ThyroiditisPolymorphismsTRPV2Type 2 Diabetes Mellitus

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Area of Science:

  • Genetics
  • Immunology
  • Endocrinology

Background:

  • Thyroid disorders are common in diabetic patients, contributing to severe complications.
  • TRPV2 ion channels play key roles in insulin secretion, glucose metabolism, and immune events relevant to diabetes and Hashimoto thyroiditis (HT).

Purpose of the Study:

  • To investigate the association of TRPV2 gene polymorphisms (rs14039 and rs4792742) with type 2 diabetes mellitus (T2DM), HT, and comorbid T2DM+HT.

Main Methods:

  • A case-control study design was employed.
  • RT-PCR genotyping was utilized to determine the rs14039 and rs4792742 polymorphisms.
  • Biochemical analyses were conducted alongside genetic analysis.

Main Results:

  • The rs14039 GG genotype and G allele were significantly more frequent in T2DM+HT patients compared to controls, increasing T2DM+HT risk 3.046-fold.
  • The rs14039 GG genotype also elevated HT risk by 2.54-fold.
  • TRPV2 rs4792742 polymorphisms demonstrated a protective effect, nearly halving the risk for HT and T2DM+HT comorbidity.

Conclusions:

  • The TRPV2 rs14039 GG genotype is linked to increased risk and potential predisposition for T2DM+HT and HT.
  • TRPV2 rs4792742 polymorphisms exhibit a significant protective role against HT and T2DM+HT comorbidity.