Related Experiment Video
Updated: Dec 14, 2025
Microvascular Decompression: Salient Surgical Principles and Technical Nuances
Published on: July 5, 2011
Does intravenous tranexamic acid reduce bleeding during mastoidectomy?
Samaneh Ziaei1, Saeid Sadeghi Joni2, Reza Shahriar3
1DDS, MS. Assistant Professor, Dept. of Dral and Maxillofacial Medicine, Faculty of Dentistry, Sharekord Branch Shahrekord, Iran.
Abstract:
Mastoidectomy is one of the important head and neck surgeries which is mostly performed due to complications of otitis media. This procedure is performed under microscopic surgery and as a result, a clean visual field is required for surgeons. Bleeding is one of the important issues during microscopic surgeries which reduces visualization. In this clinical trial, we aimed to examine effects of tranexamic acid in reducing bleeding during mastoidectomy. Here we investigated 69 patients who were candidates of mastoidectomy. Patients were randomized into two groups. In group 1, patients received tranexamic acid (10 mg/kg) at the beginning of surgeries along with other anesthetic drugs. In group 2, patients received normal saline as placebo with the same volume. Data regarding to bleeding, duration of surgeries, heart rate and blood pressure of patients were collected and analyzed. We indicated that administration of tranexamic acid is associated with significant reduced bleeding and also reduced blood pressure during surgeries (P<0.001). Taken together, we suggest that otolaryngologists should administer tranexamic acid during microscopic surgeries in order to reduce bleeding and provide a better visual field.
Insights
Tranexamic acid significantly reduces bleeding during mastoidectomy, a crucial head and neck surgery. This improves surgical visualization and patient outcomes by minimizing blood loss.
Area of Science:
- Otolaryngology
- Surgical Hemostasis
- Anesthesiology
Background:
- Mastoidectomy is a vital head and neck surgical procedure often necessitated by otitis media complications.
- Microscopic mastoidectomy demands a clear surgical field, which is frequently compromised by intraoperative bleeding.
- Effective bleeding control is paramount for successful microscopic surgical outcomes.
Purpose of the Study:
- To investigate the efficacy of tranexamic acid in mitigating blood loss during mastoidectomy.
- To assess the impact of tranexamic acid on surgical visualization and patient hemodynamic parameters.
Main Methods:
- A randomized clinical trial involving 69 patients undergoing mastoidectomy.
- Patients were allocated to receive either tranexamic acid (10 mg/kg) or a normal saline placebo.
- Data collected included bleeding volume, surgery duration, heart rate, and blood pressure.
Main Results:
- Tranexamic acid administration was associated with a statistically significant reduction in bleeding during mastoidectomy (P<0.001).
- A significant decrease in blood pressure was also observed in the tranexamic acid group.
- No significant difference in surgery duration was noted between groups.
Conclusions:
- Tranexamic acid is an effective agent for reducing intraoperative bleeding in mastoidectomy.
- The use of tranexamic acid can enhance surgical field visualization for otolaryngologists.
- Administering tranexamic acid is recommended for microscopic surgeries to improve outcomes.
