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Updated: Dec 14, 2025
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.7K
Pulmonary Manifestations in Systemic Sclerosis: Hospital-Based Descriptive Study.
Ravindrachari Mulkoju1, Vinod Kumar Saka1, Manju Rajaram1
1Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.
Cureus
|July 21, 2020
Summary
Systemic sclerosis (SSc) can cause early lung damage before symptoms appear. Diffusion lung capacity for carbon monoxide (DLco) and HRCT scans are crucial for detecting lung issues and predicting outcomes in SSc patients.
Area of Science:
- Rheumatology
- Pulmonology
- Radiology
Background:
- Systemic sclerosis (SSc) can lead to early, asymptomatic organ injury, impacting patient prognosis.
- Early identification and management of SSc-related organ damage are critical for improving outcomes.
Purpose of the Study:
- To investigate clinical manifestations and early predictors of lung involvement in Systemic Sclerosis.
- To evaluate the utility of clinical, radiological, and pulmonary function tests in early SSc lung disease detection.
Main Methods:
- 53 SSc patients meeting ACR 2013 criteria underwent clinical examination, Modified Rodnan Scoring (MRS), nailfold capillaroscopy (NFC), chest X-ray (CXR), HRCT thorax, 2D-echocardiography, spirometry, and DLco.
- Study excluded patients with overlap syndromes.
Main Results:
- Reticulonodular opacities and ground glassing on HRCT were common, suggesting non-specific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP).
- Pulmonary hypertension was prevalent in limited SSc (lcSSc). A restrictive spirometry pattern was observed in 38 patients, and 44 had abnormal DLco.
- Modified Rodnan Score (MRS) significantly correlated with pulmonary involvement detected by DLco and HRCT.
Conclusions:
- Systemic sclerosis can cause subclinical lung involvement, detectable before overt respiratory symptoms.
- DLco and HRCT are vital for early detection and outcome prediction in SSc-related lung disease.
- Higher MRS scores correlate with early visceral involvement, useful for prediction in resource-limited settings.
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