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Altered Temporal Dynamic Intrinsic Brain Activity in Late Blindness.

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Late blindness (LB) reduces dynamic brain activity in visual areas and the thalamus, indicating less flexible neural processing. This suggests altered brain dynamics may underlie visual impairment in LB.

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Brain Plasticity

Background:

  • Visual deprivation causes brain crossmodal plasticity.
  • Previous studies focused on static brain activity in blindness.
  • Dynamic intrinsic brain activity changes in late blindness remain unclear.

Purpose of the Study:

  • Investigate dynamic intrinsic brain activity alterations in late blindness (LB).
  • Assess changes in dynamic amplitude of low-frequency fluctuations (dALFFs) in LB individuals.

Main Methods:

  • Utilized sliding-window analyses to assess dynamic amplitude of low-frequency fluctuations (dALFFs).
  • Compared dALFFs between 41 late blindness (LB) cases and 48 matched sighted controls (SCs).
  • Analyzed functional connectivity (dFC) changes between brain regions.

Main Results:

  • Late blindness (LB) individuals showed significantly lower dALFFs in bilateral lingual gyrus (LING)/calcarine (CAL) and left thalamus (THA).
  • Decreased functional connectivity (dFC) was observed between visual cortices and the middle frontal gyrus, and between the thalamus and cerebellum.
  • LB cases exhibited reduced temporal variability in dALFFs within visual cortices and thalamus.

Conclusions:

  • Late blindness is associated with reduced temporal variability and flexibility in visual thalamocortical activity.
  • Abnormal dynamic intrinsic brain activity may contribute to the neurophysiological mechanisms of late blindness.
  • Findings suggest impaired visual processing in late blindness due to altered brain dynamics.