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circITGA7 Functions as an Oncogene by Sponging miR-198 and Upregulating FGFR1 Expression in Thyroid Cancer

Siqi Li1, Junmei Yang1, Xiaoting Liu1

  • 1College of Life Sciences, Inner Mongolia Normal University, Hohhot, Inner Mongolia 010022, China.

Biomed Research International
|July 21, 2020
PubMed
Abstract

Insights

Circular RNA circITGA7 is upregulated in thyroid cancer (TC), promoting cancer cell metastasis and proliferation. circITGA7 acts as a ceRNA for miR-198, regulating FGFR1 expression and potentially serving as a diagnostic marker for TC.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are functional noncoding transcripts implicated in various biological processes.
  • The specific role of circRNA circITGA7 in thyroid cancer (TC) pathogenesis was previously uncharacterized.

Purpose of the Study:

  • To investigate the expression, function, and mechanism of circRNA circITGA7 in thyroid cancer.

Main Methods:

  • Quantitative analysis of circITGA7 expression in TC cell lines and patient samples.
  • In vitro functional assays including cell proliferation and metastasis assays.
  • Mechanistic studies involving circRNA-miRNA interactions and target gene expression analysis.

Main Results:

  • circITGA7 was found to be significantly upregulated in TC cell lines and patient tissues.
  • Silencing circITGA7 inhibited proliferation and metastasis of TC cell lines.
  • circITGA7 functions as a miR-198 sponge, competitively binding to miR-198 and thereby increasing the expression of its target gene, FGFR1.

Conclusions:

  • circRNA circITGA7 plays a crucial role in promoting thyroid cancer progression.
  • circITGA7 may serve as a potential biomarker for the diagnosis and monitoring of thyroid cancer.

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