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Site engagement for multi-site clinical trials
Dana Goodlett1, Anna Hung2, Ashley Feriozzi1
1Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Contemporary Clinical Trials Communications
|July 21, 2020
Summary
Effective site engagement is crucial for successful multi-site clinical trials. This involves including local teams in planning, conducting, and disseminating research to improve enrollment, compliance, and applicability.
Area of Science:
- Clinical Research
- Medical Trials
- Public Health
Background:
- Multi-site clinical trials are vital for advancing medical treatments and generating reliable knowledge.
- The success of these trials heavily relies on local clinician and site research teams.
- Best practices for engaging these essential site teams, termed 'site engagement,' are not widely discussed.
Purpose of the Study:
- To introduce novel site engagement practices for multi-site clinical trials.
- To demonstrate how site engagement can improve trial enrollment, compliance, and local applicability.
- To provide a framework for enhancing site performance and scientific impact.
Main Methods:
- Utilized a case example from the RadComp Trial, a longitudinal, multi-site clinical trial.
- Described site engagement practices across three distinct research phases: Planning, Conducting, and Dissemination.
- Focused on active information elicitation, bi-directional communication, and leveraging partnerships.
Main Results:
- Planning Phase: Established partnerships and commitment through site-specific process elicitation and feedback.
- Conducting Phase: Fostered bi-directional communication and learning networks for improved site performance.
- Dissemination Phase: Leveraged site and community partnerships for locally designed dissemination plans.
Conclusions:
- Site engagement is a critical component for the success of multi-site clinical trials.
- The discussed practices can be adapted for various multi-site research settings.
- Implementing robust site engagement strategies enhances scientific reach and impact.
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