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Related Concept Videos

Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Updated: Dec 14, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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A proposal for staging COVID-19 coagulopathy.

Jecko Thachil1, Mary Cushman2, Alok Srivastava3

  • 1Department of Haematology Manchester University Hospitals Manchester UK.

Research and Practice in Thrombosis and Haemostasis
|July 21, 2020
PubMed
Summary

This study explores lung-centered hemostatic issues in Coronavirus disease 2019 (COVID-19) patients. It proposes staging COVID-19 coagulopathy and suggests tailored treatments for better outcomes.

Keywords:
COVID‐19anticoagulationthrombosis

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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19) is linked to severe hypercoagulability.
  • Critically ill COVID-19 patients experience thrombotic events despite anticoagulation.

Purpose of the Study:

  • To identify the lungs as the primary site of COVID-19-related hemostatic dysfunction.
  • To propose a staging system for COVID-19 coagulopathy using diagnostic markers.
  • To suggest stage-specific therapeutic strategies for COVID-19-associated coagulopathy.

Main Methods:

  • Review and synthesis of current literature on COVID-19 and coagulopathy.
  • Analysis of diagnostic markers indicative of hypercoagulable states.
  • Conceptual framework development for disease staging and treatment.

Main Results:

  • The lungs are implicated as the central organ for COVID-19-induced hemostatic abnormalities.
  • A proposed staging system for COVID-19 coagulopathy based on clinical and laboratory findings.
  • Identification of potential therapeutic targets and treatment adjustments for different disease stages.

Conclusions:

  • Understanding the lung's role in COVID-19 coagulopathy is crucial.
  • A staged approach to managing COVID-19 coagulopathy may improve patient outcomes.
  • Further research into targeted therapies for COVID-19-associated thrombosis is warranted.