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Thrombosis and thromboembolism related to COVID-19: A clarion call for obtaining solid estimates from large-scale

Stefano Barco1,2, Stavros V Konstantinides2,3,

  • 1Clinic of Angiology University Hospital Zurich Zurich Switzerland.

Research and Practice in Thrombosis and Haemostasis
|July 21, 2020
PubMed

Insights

COVID-19 patients face a high risk of thrombotic events, impacting morbidity and mortality. The CORE-THROMBOSIS registry will track these events and treatments in hospitalized patients.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19) presents a broad clinical spectrum, with severe cases involving systemic inflammation, coagulation activation, and endothelial damage.
  • These factors, combined with hypoxia and immobilization, increase the risk of life-threatening thrombotic events in COVID-19 patients.
  • Initial studies indicate thrombotic events are a significant contributor to COVID-19 morbidity and mortality.

Purpose of the Study:

  • To determine the incidence of acute thrombotic events in hospitalized COVID-19 patients.
  • To investigate current thromboprophylaxis strategies and their trends.
  • To describe the utilization of imaging for detecting cardiovascular events in COVID-19.

Main Methods:

  • Establishment of the COvid REgistry on THROMBOSIS (CORE-THROMBOSIS), a large online registry.
  • Inclusion of consecutive hospitalized patients diagnosed with COVID-19.
  • Prospective data collection on thrombotic events, prophylaxis, and diagnostic imaging.

Main Results:

  • Data collection is ongoing; specific results are pending.
  • Analysis will focus on the rate of thrombotic events, prophylaxis use, and imaging trends.

Conclusions:

  • The CORE-THROMBOSIS registry aims to provide critical insights into thrombosis in COVID-19.
  • Findings will inform clinical practice regarding prevention and management of thrombotic complications.
  • Understanding these events is crucial for improving outcomes in hospitalized COVID-19 patients.

Keywords:
COVID‐19SARS‐CoV‐2registrythrombosisvenous thromboembolism

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