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Updated: Dec 14, 2025

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Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
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High-Yielding Water-Soluble Asymmetric Cyanine Dyes for Labeling Applications
Natalia Wolf1, Louise Kersting1, Christoph Herok1
1Institute of Organic Chemistry, University of Wuerzburg, 97074 Wuerzburg, Germany.
The Journal of Organic Chemistry
|July 21, 2020
Abstract:
A simple and efficient microwave-assisted synthesis of asymmetric pentamethine cyanine dyes with various functional groups was developed, which allows high-yielding results. The synthesized dyes are modifiable and suitable for single-molecule imaging in biological and medical sciences by application of click chemistry or classic esterification and amidation.

