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Updated: Dec 14, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Tabletting solid dispersions of bicalutamide prepared using ball-milling or supercritical carbon dioxide: the
Agata Antosik-Rogóż1, Joanna Szafraniec-Szczęsny1, Karolina Gawlak2
1Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
Abstract:
The studies were aimed at formulating tablets containing bicalutamide-PVP K-29/32 solid dispersions and accessing the interrelationships between the properties of obtained binary systems in the form of powder and compacts. The effect of the compression of the solid dispersions obtained by either milling or using the supercritical fluid method on the dissolution and phase transition of the drug was investigated. Mechanical stress induced the amorphization of the drug, while the treatment with supercritical carbon dioxide did not cause any phase transition as confirmed by X-ray diffractometry. Co-processing of the drug substance with the carrier resulted in even a 10-fold improvement of the bicalutamide dissolution from the solid dispersions. The release of the drug from tablets was lower than from the corresponding powder system.
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