Related Experiment Video

Updated: Dec 14, 2025

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

15.4K

Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma

Sonia Simon Serrano1, Wondossen Sime1, Yasmin Abassi1

  • 1Department of Laboratory Medicine, Translational Cancer Research, Faculty of Medicine, Lund University, 22381, Lund, Sweden.

Scientific Reports
|July 21, 2020
PubMed

Insights

High Mps1 kinase expression predicts poor outcomes in high-risk neuroblastoma. Inhibiting Mps1 kinase triggers cancer cell death and slows tumor growth, offering a potential new therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Neuroblastoma is the most common pediatric cancer.
  • High-risk neuroblastoma patients face poor prognoses and frequent relapses.
  • Novel therapeutic strategies are crucial for refractory neuroblastoma.

Purpose of the Study:

  • To investigate the role of Mps1 kinase in neuroblastoma.
  • To evaluate Mps1 kinase as a prognostic marker.
  • To explore Mps1 kinase inhibition as a therapeutic strategy.

Main Methods:

  • Assessed Mps1 kinase expression in neuroblastoma patient samples.
  • Inhibited Mps1 kinase in neuroblastoma cell lines and patient-derived xenografts (PDX).
  • Utilized a xenograft mouse model to evaluate Mps1 inhibitor efficacy.

Main Results:

  • High Mps1 kinase expression correlated with poor relapse-free survival and overall survival.
  • Mps1 kinase inhibition induced apoptosis via the mitochondrial pathway.
  • Inhibition led to polyploidization/aneuploidization and mitotic catastrophe.
  • Mps1 inhibitor treatment retarded tumor growth in a mouse model.

Conclusions:

  • Mps1 kinase is a potential prognostic marker for high-risk neuroblastoma.
  • Mps1 kinase inhibition demonstrates therapeutic potential for neuroblastoma.
  • Targeting Mps1 kinase offers a novel treatment strategy for high-risk and refractory neuroblastoma.

More Related Videos

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.5K
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

2.0K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.4K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.5K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.0K