Atherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus

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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

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Boun Kim Tan1,2,3, Mathieu Chalouni4, Dominique Salmon Ceron2,3

  • 1Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Paris Centre, Department of Internal Medicine, Hôpital Cochin, Paris, France.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 21, 2020
PubMed

Insights

Patients with HIV and HCV coinfection face a high risk of atherosclerotic cardiovascular disease (ASCVD). Key factors include aging, prior CVD, cholesterol levels, statin use, and alcohol intake. Managing these can reduce ASCVD events.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) exhibit an elevated risk of cardiovascular disease (CVD).
  • However, specific factors contributing to atherosclerotic cardiovascular disease (ASCVD) events in this population remain underexplored.

Purpose of the Study:

  • To investigate the incidence of ASCVD events in HIV-HCV coinfected patients.
  • To identify factors associated with ASCVD events in this cohort.

Main Methods:

  • The study utilized data from the nationwide Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) CO13 HEPAVIH cohort.
  • Aalen-Johansen method estimated incidences of total, coronary/cerebral, and peripheral artery disease (PAD) ASCVD events.
  • Cause-specific Cox proportional hazards models identified associated factors.

Main Results:

  • The incidence rates per 1000 person-years were 6.98 for total ASCVD, 4.01 for coronary/cerebral ASCVD, and 3.17 for PAD ASCVD events.
  • Independent predictors of total ASCVD included aging, prior CVD, high total cholesterol, low high-density lipoprotein cholesterol, statin use, and high alcohol intake.
  • Undetectable baseline HIV RNA was associated with fewer coronary/cerebral events.

Conclusions:

  • HIV-HCV coinfected individuals experience a substantial burden of ASCVD events.
  • Traditional cardiovascular risk factors significantly influence ASCVD development in this group.
  • Effective management strategies should focus on controlling cholesterol and maintaining undetectable HIV viral load to mitigate cardiovascular risk.
Abstract

Keywords:
HIVatherosclerosiscardiovascularcoinfectionhepatitis C virus

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