Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids
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Updated: Dec 14, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Johanna Claus1,2, Thomas Eickner3, Niels Grabow2,3
1Department of Chemistry, Industrial and Applied Chemistry, University of Rostock, Albert-Einstein-Str. 3A, Rostock, 18059, Germany.
Abstract:
In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.
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