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mcr-Positive Escherichia coli ST131-H22 from Poultry in Brazil

Andre Becker S Saidenberg, Marc Stegger, Lance Bradley Price

    Emerging Infectious Diseases
    |July 21, 2020
    PubMed

    Insights

    Multidrug-resistant Escherichia coli (E. coli) ST131-H22 strains found in Brazilian poultry are closely related to international isolates. This suggests poultry may be a transmission route for these concerning bacteria. Keywords: E. coli, antimicrobial resistance, poultry, Brazil.

    Area of Science:

    • Microbiology
    • Antimicrobial Resistance
    • Food Safety

    Background:

    • Escherichia coli sequence type (ST) 131 is a globally significant pathogen.
    • This strain is known for acquiring antimicrobial resistance and causing extraintestinal infections in humans.
    • The ST131-H22 sublineage has been implicated in poultry, suggesting a potential zoonotic transmission route.

    Purpose of the Study:

    • To investigate the presence and characteristics of multidrug-resistant E. coli ST131-H22 in Brazilian poultry.
    • To compare Brazilian poultry isolates with international human and poultry isolates of the same lineage.

    Main Methods:

    • Isolation and identification of E. coli from poultry samples.
    • Antimicrobial susceptibility testing.
    • Molecular typing (e.g., whole-genome sequencing or MLST) to determine sequence type and sublineage.
    • Phylogenetic analysis to compare isolates.

    Main Results:

    • Identification of multidrug-resistant E. coli ST131-H22 in Brazilian poultry.
    • Demonstration of close genetic relatedness between Brazilian poultry isolates and international human and poultry isolates.
    • Confirmation of the ST131-H22 sublineage's presence in the Brazilian poultry population.

    Conclusions:

    • The findings confirm the circulation of multidrug-resistant E. coli ST131-H22 in Brazilian poultry.
    • Poultry serves as a potential reservoir and transmission vehicle for this concerning pathogen.
    • This highlights the need for surveillance and control measures in food-producing animals to mitigate public health risks.
    Keywords:
    Antimicrobial resistanceBrazilEscherichia coliMDRST131avian pathogenic Escherichia colicolistinphylogenetic analysespoultryvirulence factorszoonoses

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