Related Experiment Video
Updated: Dec 14, 2025

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
[Ornitine-dependent mechanisms of muscle fatigue correction and recovery from physical activity]
1Saint-Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia, St. Petersburg, Russia.
Abstract:
The article analyzes the literature data characterizing modern concepts of the mechanisms of muscle fatigue and metabolic features of recovery processes after exhausting loads. The significance of transient hyperammonium in the formation of the developed complex of fatigue manifestations in the central and peripheral links of motor units, its pathogenetic links with oxygen debt, lactacidosis, violation of ATP resynthesis, deficiency of energy-supplying substrates in working skeletal muscles, damage to muscle fibre structures, and dysfunction of various parts of the CNS is shown. The necessity of correction of hyperammoniemia associated with physical activity has been confirmed to reduce the speed of formation and expression of fatigue feeling, to reduce the risks of development of fatigue and overtraining states in sportsmen and to ensure effective course of recovery processes after exhausting physical activity. It was revealed that ornithine-containing preparations can be used for correction of post-load hyperammonium and acceleration of recovery processes. The data characterizing the high efficiency of L-ornitine-L-aspartate in sports medicine practice are presented.
More Related Videos
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
07:20Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
Published on: September 10, 2014
Related Concept Videos
Muscle Recovery and Fatigue
Energy Supply for Muscle Contraction
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Relaxation of Skeletal Muscles
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
Cross-bridge Cycle
Formation of Muscle Fibers from Myoblasts
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...