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Related Experiment Video

Updated: Dec 14, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy.

Bingbing Sun1, Rui Chang2, Shoupeng Cao1

  • 1Bio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.

Angewandte Chemie (International Ed. in English)
|July 21, 2020
PubMed
Summary

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The New England journal of medicine·2026

Researchers created pH-responsive peptide nanoparticles that transform into nanofibers in tumors. This enhances photodynamic therapy (PDT) effectiveness and allows for prolonged tumor retention and imaging.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Therapy

Background:

  • Biological systems exhibit dynamic morphology control in molecular assemblies.
  • Developing effective drug delivery systems for cancer therapy remains a challenge.
  • Stimuli-responsive nanomaterials offer potential for targeted treatments.

Purpose of the Study:

  • To develop pH-responsive peptide-based nanoparticles for photodynamic therapy (PDT).
  • To achieve prolonged tumor retention times and enhanced therapeutic efficacy.
  • To investigate the transformation of nanoparticles into nanofibers in the tumor microenvironment.

Main Methods:

  • Self-assembly of peptide-porphyrin nanoparticles.
  • Exposure to acidic conditions mimicking the tumor microenvironment.
Keywords:
fibrillar transformationpeptidesphotodynamic therapyphotosensitizersself-assembly

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  • Analysis of nanoparticle morphology transformation (nanoparticles to nanofibers).
  • Evaluation of singlet oxygen generation.
  • In vivo studies for tumor accumulation, retention, and anti-tumor efficacy assessment.

    • Main Results:

    • Peptide-porphyrin nanoparticles transformed into nanofibers in response to acidic pH.
    • This transformation was driven by enhanced intermolecular hydrogen bond formation.
    • Nanofiber formation improved singlet oxygen generation, leading to high tumor accumulation and retention for up to 7 days.
    • Significant anti-tumor efficacy was observed in vivo via PDT.

    Conclusions:

    • pH-responsive peptide-based nanoparticles can transform into nanofibers for enhanced PDT.
    • This in situ fibrillar transformation strategy promotes prolonged tumor retention and therapeutic effects.
    • The developed biomaterials show promise for long-term imaging and therapy applications.