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Neuropathogenic human coronaviruses: A review.
Osama S Abdelaziz1, Zuraiha Waffa1
1Neurosurgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Reviews in Medical Virology
|July 21, 2020
Summary
Human coronaviruses (HCoVs) can affect the nervous system, leading to neurological issues. Early detection of neurotropism and risk factors is crucial during outbreaks like COVID-19.
Area of Science:
- Neurology
- Virology
- Infectious Diseases
Background:
- Human coronaviruses (HCoVs) are primarily known as respiratory pathogens.
- Neurological complications have been increasingly reported in HCoV infections, especially during the COVID-19 pandemic caused by SARS-CoV-2.
Purpose of the Study:
- To analyze the impact of HCoVs, particularly SARS-CoV-2, on the nervous system.
- To elucidate the mechanisms, neurological manifestations, and risk factors associated with HCoV-induced neurological conditions.
Main Methods:
- A comprehensive literature review was conducted.
- Analysis focused on existing studies detailing HCoV interactions with the nervous system.
Main Results:
- HCoV infections, including SARS-CoV-2, are associated with a significant range of neurological conditions.
- The review identified various underlying mechanisms and neurological risk factors.
Conclusions:
- Understanding HCoV neurotropism is vital for managing outbreaks like COVID-19.
- Early detection of neurological complications and risk factors can alleviate healthcare burdens, especially in intensive care and neurology departments.
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