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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Development and function of human dendritic cells in humanized mice models.

Giorgio Anselmi1, Julie Helft2, Pierre Guermonprez3

  • 1King's College London, Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immunobiology, United Kingdom.

Molecular Immunology
|July 21, 2020
PubMed
Summary

Humanized mice models (HIS mice) allow researchers to study human dendritic cells (DCs) development and function in vivo. These models are crucial for understanding immune responses and advancing immunology research.

Keywords:
Dendritic cellsEngineered stromal cellsHumanized miceNSG

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Area of Science:

  • Immunology
  • Hematopoiesis
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial immune sentinels originating from hematopoietic stem cells.
  • DCs regulate both adaptive and innate lymphocyte responses.
  • Effective experimental models are needed to study human DC development and function.

Purpose of the Study:

  • To review methods for recapitulating human dendritic cell (DC) subset ontogeny in human immune system (HIS) mice.
  • To discuss studies utilizing HIS mice to investigate human DC biology in vivo.

Main Methods:

  • Review of experimental approaches for DC development in HIS mice.
  • Analysis of studies on human DC subsets within HIS mouse models.

Main Results:

  • HIS mice models successfully recapitulate human DC ontogeny.
  • Studies in HIS mice provide insights into human DC subset biology.

Conclusions:

  • Humanized mice models are valuable tools for studying human dendritic cell development and function.
  • HIS mice facilitate in vivo investigation of human immune cell behavior and responses.