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Phthalate exposure linked to high blood pressure in Chinese children

Yao Yao1, Ding-Yan Chen2, Jiang-Wei Yin3

  • 1Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China; Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Environment International
|July 21, 2020
PubMed

Insights

Phthalate metabolite exposure, particularly Monomethyl phthalate (MMP), is linked to increased high blood pressure (HBP) risk and elevated blood pressure metrics in Chinese children. This study highlights potential environmental health concerns for pediatric populations.

Area of Science:

  • Environmental Health
  • Pediatric Cardiology
  • Toxicology

Background:

  • Phthalate ester exposure is a potential risk factor for high blood pressure (HBP).
  • Limited evidence exists regarding phthalate exposure and HBP in Chinese children.

Purpose of the Study:

  • To investigate associations between nine phthalate metabolites (mPAEs) and blood pressure (BP) parameters.
  • To assess the relationship between mPAEs and the risk of HBP in primary school children.

Main Methods:

  • Cross-sectional study of 1044 children (6-8 years) in Shenzhen, China.
  • Urine analysis of nine mPAEs using ultra-performance liquid chromatography and tandem mass spectrometry.
  • Multivariable and binary logistic regression models to analyze associations with BP and HBP risk.

Main Results:

  • Monomethyl phthalate (MMP) levels were higher in children with HBP.
  • Several mPAEs, including MMP, were positively associated with systolic BP, pulse pressure (PP), and mean arterial pressure (MAP).
  • MMP showed a significant association with increased HBP risk (OR=1.87).

Conclusions:

  • Dimethyl phthalate exposure is suggested to increase HBP risk in children.
  • Specific phthalates are associated with elevated BP metrics in Chinese children, indicating a potential public health concern.
Abstract

Keywords:
Blood pressureChildrenExposureHypertensionPhthalate metabolites

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