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Updated: Dec 14, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Natural sesquiterpenoid oligomers: A chemical perspective
Wen-Yu Zhao1, Juan-Juan Yan1, Tian-Tian Liu1
1Institute of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian, China.
Abstract:
Sesquiterpenoid oligomers, biogenetically assembled by at least two monomeric sesquiterpenoid units via diverse pathways, represent a unique class of natural products with distinct bioactivities. Herein, we provide a review covering the dimeric, trimeric, and tetrameric sesquiterpenoids categorized by reaction types in biosynthesis from a chemical perspective. Emphasis is focused on the biosynthetic oligomerization pathways of these interesting molecules and their related biological functions, which will supply inspiration for the total synthesis or biomimetic synthesis of more oligomeric sesquiterpenoids and further pharmacological investigations.
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