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Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
Published on: June 17, 2012
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Review: Metabolome characterisation in plant system analysis
1Department of Lothar Willmitzer, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14 476 Golm, Germany.
Functional Plant Biology : FPB
|July 22, 2020
Summary
Plant biology is shifting to systems-based approaches, moving beyond gene sequencing to functional analysis. This review highlights high-throughput metabolomics and discusses its future in plant systems biology research.
Area of Science:
- Plant Biology
- Systems Biology
- Metabolomics
Background:
- Plant biology research is transitioning from reductionist to holistic, systems-based approaches.
- Advances in technology and genomics, including the Arabidopsis genome sequence, facilitate this shift.
- The focus is moving from gene identification to functional characterization of gene products.
Purpose of the Study:
- To review high-throughput metabolite analysis methods for plant systems.
- To emphasize techniques for determining steady-state metabolite concentrations.
- To discuss the adoption of metabolic flux analysis in plant studies.
Main Methods:
- High-throughput metabolite analysis techniques.
- Morphological analyses.
- Analytical profiling of mRNA transcripts, proteins, and metabolites.
- Metabolic flux analysis.
Main Results:
- High-throughput metabolomics enables comprehensive analysis of biological systems.
- Steady-state metabolite concentrations can be determined for a broad spectrum of metabolites.
- Metabolic flux analysis shows potential for application in plant systems.
Conclusions:
- Metabolomics is a key component of modern plant systems biology.
- High-throughput methods are crucial for understanding plant responses to perturbations.
- Future prospects involve integrating metabolome analysis within a broader systems biology framework.
