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Related Experiment Video

Updated: Dec 14, 2025

Microfluidics in Assessing Platelet Function
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Mean platelet volume and mechanical thrombectomy.

Francisco Sabença1, Andreia Carvalho2, Mariana Rocha2

  • 1Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia; Rua da Cruz n°101, 3° Andar, 4200-248 Porto.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|July 22, 2020
PubMed
Summary
This summary is machine-generated.

This study found no link between higher Mean Platelet Volume (MPV) and worse outcomes in stroke patients undergoing mechanical thrombectomy. MPV may have different prognostic value depending on the stroke

Keywords:
Acute ischemic strokeFunctional outcomeMean Platelet VolumeMechanical ThrombectomyStroke Subtypes

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Area of Science:

  • Neurology
  • Hematology
  • Cardiovascular Research

Background:

  • Mean Platelet Volume (MPV) is a recognized indicator of platelet activation.
  • MPV is an established independent predictor of long-term prognosis in patients who have experienced a stroke.

Purpose of the Study:

  • To investigate the relationship between baseline MPV levels and 90-day clinical outcomes.
  • To assess MPV's association with outcomes in patients with anterior circulation stroke and large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT).

Main Methods:

  • Prospective observational cohort study of acute ischemic stroke (AIS) patients undergoing MT.
  • MPV measured at admission; patients stratified by mean MPV level, a specific cut-off (10.4 fL), and MPV terciles.
  • Evaluated associations with functional outcome, recanalization success, and mortality at 3 months.

Main Results:

  • 129 patients were analyzed; mean MPV was 10.9 fL.
  • Embolic stroke of undetermined source (ESUS) showed higher good outcomes (82.9%) compared to large-artery atherosclerosis (78.3%) and cardioembolism (55.2%) (p=0.009).
  • No significant differences in MPV, recanalization, or mortality were found across TOAST etiologies, MPV groups, or terciles regarding 3-month outcomes.

Conclusions:

  • The study did not establish a correlation between elevated MPV and adverse 3-month outcomes in anterior circulation stroke/LVO patients treated with MT.
  • MPV's prognostic utility may vary based on the specific pathophysiologic mechanisms of different ischemic stroke etiologies.