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Updated: Dec 14, 2025
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Mean platelet volume and mechanical thrombectomy
Francisco Sabença1, Andreia Carvalho2, Mariana Rocha2
1Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia; Rua da Cruz n°101, 3° Andar, 4200-248 Porto.
Background And Purpose:
Mean Platelet Volume (MPV) is a marker of platelet activity and it is an independent predictor for long-term outcome in stroke patients. The aim of this study was to evaluate the association between baseline MPV value and clinical outcome at 90-days in anterior circulation stroke and large vessel occlusion (LVO) patients submitted to mechanical thrombectomy (MT).
Methods:
We conducted a prospective observational cohort study in acute ischemic stroke (AIS) patients submitted to MT between January 2017 and May 2018. MPV was measured at admission. Patients were initially stratified into two groups according to the mean MPV level. We also compared groups that were stratified according to the MPV cut-off obtained by Peng F et al (10,4 fL) and performed analyses among MPV terciles.
Results:
A total of 129 patients were included. Mean level of MPV was 10,9 fL. Patients with embolic stroke of undetermined source (ESUS) had significantly higher rates of good outcome at 3 months compared with large-artery atherosclerotic disease and cardioembolism [(82,9%) vs (78,3%) vs (55,2%); p=0,009]. There were no statistically significant differences in the mean MPV value (p=0,222), successful recanalization (p=0,464) and mortality (p=0,343) when evaluated for all TOAST etiologies. There were no statistically significant differences between the two groups according to the MPV level (10,4 and 10,9 fL) or between the terciles (lowest tertile <10,3 fL, median 10,3 - 11,3 fL, highest >11,3fL) concerning functional outcome at 3 months (p=0,357; p=0,24 and p=0,558, respectively), successful recanalization (p=0,108; p=0,582 and p=0,899, respectively) or mortality at 3 months (p=0,465; p=0,061 and p=0,484, respectively).
Conclusion:
Our study did not find an association between elevated MPV and worse outcome at 3 months in patients with acute anterior circulation stroke and LVO treated with MT. Since ischemic strokes have different pathophysiologic mechanisms, MPV may have distinct prognostic value according to each stroke etiology.
Insights
This study found no link between higher Mean Platelet Volume (MPV) and worse outcomes in stroke patients undergoing mechanical thrombectomy. MPV may have different prognostic value depending on the stroke
Area of Science:
- Neurology
- Hematology
- Cardiovascular Research
Background:
- Mean Platelet Volume (MPV) is a recognized indicator of platelet activation.
- MPV is an established independent predictor of long-term prognosis in patients who have experienced a stroke.
Purpose of the Study:
- To investigate the relationship between baseline MPV levels and 90-day clinical outcomes.
- To assess MPV's association with outcomes in patients with anterior circulation stroke and large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT).
Main Methods:
- Prospective observational cohort study of acute ischemic stroke (AIS) patients undergoing MT.
- MPV measured at admission; patients stratified by mean MPV level, a specific cut-off (10.4 fL), and MPV terciles.
- Evaluated associations with functional outcome, recanalization success, and mortality at 3 months.
Main Results:
- 129 patients were analyzed; mean MPV was 10.9 fL.
- Embolic stroke of undetermined source (ESUS) showed higher good outcomes (82.9%) compared to large-artery atherosclerosis (78.3%) and cardioembolism (55.2%) (p=0.009).
- No significant differences in MPV, recanalization, or mortality were found across TOAST etiologies, MPV groups, or terciles regarding 3-month outcomes.
Conclusions:
- The study did not establish a correlation between elevated MPV and adverse 3-month outcomes in anterior circulation stroke/LVO patients treated with MT.
- MPV's prognostic utility may vary based on the specific pathophysiologic mechanisms of different ischemic stroke etiologies.
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