Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.0K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

517
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
517
Seizures: Classification01:13

Seizures: Classification

1.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

769
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
769
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

1.4K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.4K
Psychosurgery01:30

Psychosurgery

452
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
452

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accuracy of Surgeon's Estimate of Gross Total Resection After Endoscopic Endonasal Trans-sphenoidal Surgery for Non-Hormone-Producing Pituitary Macroadenomas: Does It Matter?

Neurosurgery practice·2026
Same author

The Magnet-Actuated Craniofacial (MAC) Distraction System: Magnetic Coupling Modeling.

Annals of biomedical engineering·2026
Same author

The Negative Impact of External Activation Ports on Cranial Distraction: Systematic Review of the Literature and Proportional Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

Rethinking the role of surgery and radiotherapy in BRAF-mutant papillary craniopharyngioma: a position statement from the neurosurgical perspective.

Neurosurgical focus·2026
Same author

Endoscopic endonasal gross-total resection of pediatric craniopharyngioma invading the hypothalamus: rethinking the role of surgery.

Neurosurgical focus·2026
Same author

Letter: Optimizing Endoscopic Approaches for Sphenoid Lateral Recess Cerebrospinal Fluid Leaks: Proposal of a New Algorithm.

Operative neurosurgery (Hagerstown, Md.)·2026

Related Experiment Video

Updated: Dec 14, 2025

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.6K

Challenges of Epilepsy Surgery.

Claudia M Kuzan-Fischer1, Whitney E Parker1, Theodore H Schwartz1

  • 1Department of Neurological Surgery, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York, USA.

World Neurosurgery
|July 22, 2020
PubMed
Summary

Epilepsy surgery can effectively manage refractory seizures but requires careful patient selection and planning. Addressing challenges in identifying the seizure focus and network is crucial for successful outcomes and minimizing cognitive side effects.

Keywords:
Epilepsy surgeryNoninvasive and invasive diagnostic toolsPatient selectionSeizure networkTreatment modalities

More Related Videos

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

17.8K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K

Related Experiment Videos

Last Updated: Dec 14, 2025

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.6K
Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

17.8K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K

Area of Science:

  • Neurosurgery
  • Epileptology
  • Neurology

Background:

  • Epilepsy surgery is a key treatment for medically refractory seizures.
  • Patient selection and precise identification of the seizure focus are critical for success.
  • Surgery aims to achieve seizure freedom while preventing neurocognitive deficits.

Purpose of the Study:

  • To review the challenges associated with epilepsy surgery.
  • To highlight strategies for patient selection and surgical planning.
  • To discuss various surgical and neuromodulation techniques.

Main Methods:

  • Review of current epilepsy surgery strategies.
  • Discussion of diagnostic techniques for seizure focus localization.
  • Overview of therapeutic interventions including resection and neuromodulation.

Main Results:

  • Successful epilepsy surgery depends on meticulous interdisciplinary planning.
  • Multiple surgical and neuromodulation options exist to target epileptic foci and networks.
  • Non-invasive techniques like focused ultrasound offer new avenues for treatment.

Conclusions:

  • Careful consideration of patient selection and surgical strategy is paramount for successful epilepsy surgery.
  • A multidisciplinary approach is essential for optimizing outcomes.
  • Advances in surgical techniques and neuromodulation continue to improve epilepsy management.