Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Let's Get Moving: Surgically Facilitated Orthodontic Therapy to Enhance Orthodontic Outcomes.

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2026

Same author

An in vitro comparison of PDGF-BB release from composite graft materials containing leukocyte-rich platelet-rich fibrin and platelet-derived growth factor-BB and β-tricalcium phosphate.

Journal of periodontology·2026

Same author

Extent of Implantoplasty in the Combined Surgical Therapy of Peri-Implantitis: A Quasi-Randomized Clinical Trial.

Clinical implant dentistry and related research·2026

Same author

The Clinical Significance of Attached Gingiva in the Natural Dentition.

Dentistry journal·2026

Same author

Penicillin Allergy and Dental Implant Outcomes: A Review.

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2026

Same author

Clinical Implication of Bone Defect Morphology in Peri-implantitis Therapy.

The International journal of periodontics & restorative dentistry·2026

Search research articles

Related Experiment Video

Updated: Dec 14, 2025

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Periodontal Regeneration - Intrabony Defects: Practical Applications From the AAP Regeneration Workshop.

Mark A Reynolds¹, Richard T Kao^2,3, Salvador Nares⁴

¹Department of Periodontics, School of Dentistry, University of Maryland, Baltimore, MD.

Clinical Advances in Periodontics

|July 22, 2020

Summary

Predictable regeneration of intrabony defects is achievable with various periodontal regenerative therapies. Long-term success depends on patient factors, defect morphology, and consistent supportive care.

Keywords:

Bone transplantation guided tissue regeneration periodontitis regeneration surgery, oral

More Related Videos

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

Related Experiment Videos

Last Updated: Dec 14, 2025

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

Area of Science:

Periodontal regeneration
Intrabony defect management
Regenerative surgical approaches

Background:

Intrabony defects are a significant challenge in periodontitis management.
Periodontal regeneration aims to restore lost tissues, improving periodontal health.
Multiple regenerative therapies exist, including grafts, guided tissue regeneration, and biologics.

Purpose of the Study:

To identify key considerations for selecting predictable regenerative surgical approaches for intrabony defects.
To evaluate factors influencing the success of periodontal regeneration.

Main Methods:

Review of clinical and histologic evidence for various regenerative therapies.
Analysis of patient-related factors (e.g., smoking) and defect/site-related factors (e.g., morphology, number of bony walls).

Main Results:

Regenerative therapies demonstrate clinical improvements like attachment gain and probing depth reduction.
Regeneration predictability is influenced by defect complexity and patient factors.
Combination therapies may be required for challenging defects.

Conclusions:

Periodontal regeneration of intrabony defects is feasible with diverse strategies.
Long-term success requires integration with oral hygiene and supportive periodontal maintenance.