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Related Experiment Video

Updated: Dec 14, 2025

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Genetically predicted iron status and life expectancy.

Iyas Daghlas1, Dipender Gill2

  • 1Harvard Medical School, Boston, MA, USA.

Clinical Nutrition (Edinburgh, Scotland)
|July 22, 2020
PubMed
Summary

Higher iron levels may shorten lifespan. This Mendelian randomization study found that increased genetically predicted serum iron is associated with reduced parental lifespan and lower odds of long-term survival.

Keywords:
FerritinIronLifespanLongevityMendelian randomizationTransferrin

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Area of Science:

  • Genetics
  • Epidemiology
  • Longevity Research

Background:

  • Systemic iron status influences numerous health outcomes.
  • The precise impact of iron status on overall life expectancy remains unclear.

Purpose of the Study:

  • To investigate the association between genetically determined iron status and life expectancy using a two-sample Mendelian randomization approach.

Main Methods:

  • Utilized genetic data from 48,972 individuals to identify genetic variants for systemic iron status.
  • Employed inverse-variance weighted methods to assess the relationship between genetically predicted serum iron and parental lifespan and individual survival.
  • Analyzed associations with parental lifespan (n=1,012,240) and survival to advanced age.

Main Results:

  • A one-standard deviation increase in genetically predicted serum iron was linked to a reduction of 0.70 years in parental lifespan (P=3.00×10⁻³).
  • Higher genetically predicted serum iron was associated with decreased odds of survival to older age (OR=0.81, P=4.44×10⁻³).
  • No significant evidence of pleiotropic effects biasing the results was found.

Conclusions:

  • Elevated systemic iron status may be detrimental to life expectancy.
  • Further research is needed to explore the clinical implications, especially concerning iron supplementation in individuals with normal iron levels.