Revised D-A-CH Reference Values for the Intake of Vitamin B6

Area of Science:

• Nutritional Science
• Human Physiology
• Public Health Nutrition

Background:

• The D-A-CH reference values for nutrient intake were revised in 2019.
• This revision specifically addressed the reference values for vitamin B6.

Purpose of the Study:

• To establish updated average requirements (AR) and recommended intakes (RI) for vitamin B6.
• To define vitamin B6 requirements across various age groups, including infants, children, adolescents, adults, pregnant, and lactating women.

Main Methods:

• Average requirements (AR) for adult women were determined using balance studies and plasma pyridoxal-5'-phosphate (PLP) concentrations.
• Recommended intakes (RI) were calculated considering a coefficient of variation.
• Requirements for other groups were extrapolated from adult female requirements, accounting for body weight, growth, and physiological status.

Main Results:

• The AR for adult females is 1.2 mg/day, and for adult males is 1.3 mg/day, aiming for a PLP of ≥30 nmol/L.
• The RI for adult females is 1.4 mg/day, and for adult males is 1.6 mg/day.
• Specific estimated and extrapolated values were provided for infants, children, adolescents, pregnant, and lactating women, with RIs ranging from 0.3 mg/day to 1.8 mg/day.

Conclusions:

• The revised D-A-CH reference values provide updated guidance on vitamin B6 intake.
• These values are crucial for maintaining adequate vitamin B6 status across the population.
• The updated recommendations consider diverse physiological needs, from infancy to lactation.