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Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

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High affinity heparin detection by multivalent supramolecular polymers through aggregation induced emission.

Shubhra Kanti Bhaumik¹, Yoti Shankar Patra¹, Supratim Banerjee¹

¹The Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, Nadia, India. supratim.banerjee@iiserkol.ac.in.

Chemical Communications (Cambridge, England)

|July 22, 2020

Summary

Novel luminescent polymers detect heparin, a blood thinner, using aggregation-induced emission. This breakthrough enables sensitive detection of heparin in biological samples like serum and plasma.

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Area of Science:

Supramolecular chemistry
Materials science
Biomedical diagnostics

Background:

Cyanostilbene derivatives exhibit aggregation-induced emission (AIE).
AIE materials form luminescent supramolecular polymers in aqueous media.
Heparin is a vital anticoagulant and a biologically relevant polyanion.

Purpose of the Study:

To develop a sensitive method for heparin detection.
To explore the formation of co-assemblies between AIE-active polymers and heparin.
To investigate the potential of these systems for biomedical applications.

Main Methods:

Synthesis of amphiphilic di-cationic cyanostilbene derivatives.
Formation of luminescent supramolecular polymers in aqueous solutions.
Investigation of co-assembly formation with heparin using fluorescence spectroscopy.
Detection of heparin in buffer, human serum, and plasma.

Main Results:

Amphiphilic di-cationic cyanostilbene derivatives formed luminescent supramolecular polymers.
These polymers effectively bound heparin in a multivalent manner, forming co-assemblies.
Co-assembly formation led to significantly enhanced greenish-yellow emission.
Heparin was detected at nanomolar concentrations in buffer and at medically relevant levels in human serum and plasma.

Conclusions:

AIE-active supramolecular polymers can be utilized for sensitive heparin detection.
The developed system demonstrates high sensitivity and applicability in biological fluids.
This approach offers a promising tool for anticoagulant monitoring and diagnostics.