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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
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[Botulinum toxin for overactive bladder]
B K Ziegelmüller1, A Sommer2, R M Bauer2
1Urologische Klinik und Poliklinik, Klinikum der Ludwig-Maximilians-Universität München, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland. Brigitte.Ziegelmueller@med.uni-muenchen.de.
Der Urologe. Ausg. A
|July 22, 2020
Summary
Idiopathic overactive bladder (OAB) is a condition causing urinary urgency and frequency. For refractory cases, onabotulinum toxin A injections offer a safe and effective treatment option with lasting effects.
Area of Science:
- Urology
- Pharmacology
Background:
- Idiopathic overactive bladder (OAB) presents as urinary urgency, frequency, and nocturia without infection or neurological causes.
- It is a diagnosis of exclusion, often managed with conservative therapies first.
- Pharmaceuticals are recommended if behavioral therapies fail, following a staged treatment approach.
Purpose of the Study:
- To evaluate onabotulinum toxin A as a treatment for refractory idiopathic overactive bladder (OAB).
- To highlight its efficacy, safety, and suitability as a therapeutic option.
Main Methods:
- Intravesical injection of 100 U onabotulinum toxin A into the detrusor muscle.
- Treatment administered transurethrally.
- Repeat injections are permissible without limitations.
Main Results:
- Onabotulinum toxin A provides a treatment effect lasting an average of 6-9 months.
- The procedure is associated with a low complication rate.
- A good success rate is observed in patients with treatment-refractory OAB.
Conclusions:
- Onabotulinum toxin A is recommended by current guidelines for refractory OAB (Recommendation Level A).
- Its low invasiveness, good success rate, and low complication profile make it a viable treatment option.
- Repeated injections can be safely administered, offering sustained management for OAB symptoms.
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