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Updated: Dec 14, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Assessing Stress in Pregnancy and Postpartum: Comparing Measures
Irena Štěpáníková1,2,3, Elizabeth Baker4, Gabriela Oates5
1Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic. irena@uab.edu.
Measuring early-life stress is complex. Combining psychological distress measures with stressful life event (SLE) counts best predicts offspring emotional and behavioral difficulties (EBD) across childhood and adolescence.
Area of Science:
- Developmental Psychology
- Perinatal Mental Health
- Child Psychiatry
Background:
- Assessing early-life psychosocial stress presents methodological challenges.
- Understanding the impact of stress timing on child emotional and behavioral difficulties (EBD) is crucial.
- This study compares three instruments for measuring life stress during pregnancy and postpartum.
Purpose of the Study:
- To compare the effectiveness of three survey instruments in assessing perinatal life stress.
- To investigate how the timing of early-life stress influences offspring EBD from childhood to adolescence.
- To identify optimal methods for predicting long-term child behavioral outcomes.
Main Methods:
- Utilized data from 4811 pregnancies in the European Longitudinal Cohort Study of Pregnancy and Childhood (ELSPAC-CZ).
- Assessed life stress using the Edinburgh Postnatal Depression Scale (EPDS), a stressful life events (SLE) count, and a perceived stressfulness-weighted SLE measure at three perinatal time points.
- Measured child EBD with the Strengths and Difficulties Questionnaire from age 7 to 18 years.
Main Results:
- All stress measures independently predicted long-term EBD in offspring.
- A combined model using EPDS and SLE provided the best data fit for predicting EBD.
- The impact of SLEs on EBD diminished from early pregnancy to postpartum, while the effect of EPDS increased.
Conclusions:
- Stressful life event (SLE)-based methods capture unique aspects of perinatal stress beyond psychological distress (EPDS).
- Combining psychological distress and SLE measures offers an optimal approach for predicting child EBD.
- SLE measures are best suited for early pregnancy, while self-reported depressive symptoms (EPDS) may be more effective postpartum.
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