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Zachary M Weil1, Laura K Fonken2, William H Walker1

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Area of Science:

  • Chronobiology
  • Neuroscience
  • Pathophysiology

Background:

  • Circadian rhythms regulate physiological and behavioral functions, synchronized by natural light-dark cycles.
  • Artificial light at night (LAN) disrupts these endogenous rhythms, potentially impacting health.
  • Hospitalized patients are vulnerable to LAN due to compromised health states.

Purpose of the Study:

  • To investigate the impact of dim light at night (dLAN) on stroke recovery.
  • To test the hypothesis that dLAN impairs the response to ischemic injury.

Main Methods:

  • A mouse model of stroke (middle cerebral artery occlusion; MCAO) was utilized.
  • Animals were exposed to dLAN or kept in dark nights following stroke induction.
  • Stroke lesion size and post-stroke anxiety-like behaviors were assessed.

Main Results:

  • Stroke lesion size was significantly larger in mice exposed to dLAN compared to those in dark conditions.
  • Mice housed in dLAN exhibited increased anxiety-like behavior three days post-stroke.
  • dLAN exposure amplified pro-inflammatory pathways in the central nervous system (CNS).

Conclusions:

  • Exposure to dim light at night is detrimental to stroke recovery.
  • dLAN may exacerbate neuronal damage by amplifying pro-inflammatory responses.
  • Minimizing light at night could be beneficial for patients recovering from stroke.