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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

791
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
791
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

676
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
676
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

731
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
731
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

339
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
339
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

857
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Related Experiment Video

Updated: Dec 14, 2025

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

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Perianal Crohn's Disease.

Amy L Lightner1

  • 1Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio.

Diseases of the Colon and Rectum
|July 22, 2020
PubMed
Summary

A young man with a perianal abscess was diagnosed with Crohn's disease (CD) after imaging and colonoscopy. Treatment with monoclonal antibodies improved his fistula symptoms.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Inflammatory Bowel Disease

Background:

  • Perianal abscesses can be an early manifestation of Crohn's disease (CD), particularly in young adults.
  • Early diagnosis and management are crucial for improving patient outcomes and preventing complications associated with CD.

Purpose of the Study:

  • To present a case of a young male patient with a perianal abscess initially managed surgically.
  • To highlight the diagnostic process for identifying underlying Crohn's disease (CD) in the context of perianal disease.
  • To illustrate the initial response to biologic therapy in a patient with newly diagnosed CD and perianal involvement.

Main Methods:

  • Initial presentation and surgical management of a perianal abscess with seton placement.
  • Diagnostic workup including examination under anesthesia (EUA), magnetic resonance enterography (MRE), and colonoscopy.

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  • Initiation of treatment with a monoclonal antibody for confirmed Crohn's disease (CD).

    • Main Results:

    • Magnetic resonance enterography (MRE) revealed inflammation in the distal terminal ileum.
    • Colonoscopy identified multiple small ulcers in the terminal ileum, consistent with Crohn's disease (CD).
    • Following three infusions of a monoclonal antibody, the patient reported significant improvement in perianal fistula drainage.

    Conclusions:

    • Perianal abscesses in young adults warrant a thorough investigation for underlying inflammatory bowel disease, such as Crohn's disease (CD).
    • A combination of advanced imaging and endoscopic evaluation is essential for accurate diagnosis.
    • Monoclonal antibody therapy shows promise in managing both the intestinal and perianal manifestations of Crohn's disease (CD).