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Potential Repurposed Therapeutics and New Vaccines against COVID-19 and Their Clinical Status
Abid H Banday1,2, Shameem A Shameem2, Sheikh J Ajaz3
1Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama, USA.
Insights
This review highlights ongoing research into treatments and vaccines for SARS-CoV-2, the virus causing COVID-19. It details the scientific basis, clinical progress, and timelines for key therapeutic candidates to aid researchers.
Area of Science:
- Virology and Epidemiology
- Infectious Diseases
- Public Health
Background:
- Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019, rapidly escalating into a global pandemic.
- As of June 12, 2020, over 7.30 million infections and 413,000 deaths were reported worldwide, with the United States experiencing significant impact.
- The pandemic necessitates a comprehensive strategy including screening, therapy development, and vaccine research for long-term control.
Purpose of the Study:
- To provide an overview of current therapeutic and preventative strategies against SARS-CoV-2 infection.
- To detail the scientific background, clinical trial status, and projected timelines for investigational drugs and vaccines.
- To serve as a resource for the scientific community and researchers by consolidating critical clinical information on SARS-CoV-2 therapeutics.
Main Methods:
- Review of ongoing research and clinical trials for SARS-CoV-2 therapeutics and vaccines.
- Compilation of scientific data, clinical status updates, and development timelines for selected drug candidates.
- Information gathering updated as of June 12, 2020.
Main Results:
- Multiple pharmaceutical companies, academic institutions, and government organizations are actively investigating novel therapeutics and repurposing existing drugs.
- Significant progress is being made in identifying and evaluating various treatment options and vaccine candidates.
- The article synthesizes key clinical information on the most prominent therapeutic candidates.
Conclusions:
- A multipronged approach involving drug repurposing and new therapeutic development is crucial for combating the COVID-19 pandemic.
- Continued research and clinical evaluation are essential to identify effective treatments and vaccines.
- This review offers valuable, up-to-date clinical insights for researchers engaged in the fight against SARS-CoV-2.
Abstract:
SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), was first reported in Wuhan, China, in December 2019. Since then, the virus has stretched its grip to almost all the countries in the world, affecting millions of people and causing enormous casualties. The World Health Organization (WHO) declared COVID-19 a pandemic on March 11, 2019. As of June 12, 2020, almost 7.30 million people have already been infected globally, with 413,000 reported casualties. In the United States alone, 2.06 million people have been infected and 115,000 have succumbed to this pandemic. A multipronged approach has been launched toward combating this pandemic, with the main focus on exhaustive screening, developing efficacious therapies, and vaccines for long-term immunity. Several pharmaceutical companies in collaboration with various academic institutions and governmental organizations have started investigating new therapeutics and repurposing approved drugs so as to find fast and affordable treatments against this disease. The present communication is aimed at highlighting the efforts that are currently underway to treat or prevent SARS-CoV-2 infection, with details on the science, clinical status, and timeline for selected investigational drugs and vaccines. This article is going to be of immense help to the scientific community and researchers as it brings forth all the necessary clinical information of the most-talked-about therapeutics against SARS-CoV-2. All the details pertaining to the clinical status of each therapeutic candidate have been updated as of June 12, 2020.
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