Related Experiment Video

Updated: Dec 14, 2025

Isolation of Lung Retinoid-Containing Cells by Cell Sorting
07:47

Isolation of Lung Retinoid-Containing Cells by Cell Sorting

Published on: April 11, 2025

576

Resistin family proteins in pulmonary diseases

Qing Lin1, Roger A Johns1

  • 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|July 22, 2020
PubMed

Insights

Resistin-like molecules (RELMs) are key cytokines involved in lung diseases like pulmonary hypertension and asthma. Understanding RELM signaling may lead to new treatments for respiratory and cardiovascular conditions.

Area of Science:

  • Immunology
  • Pulmonology
  • Molecular Biology

Background:

  • Resistin-like molecules (RELMs) are cytokines with inflammation-regulating, chemokine, and growth factor properties.
  • RELMs play significant roles in both physiological and pathophysiological processes, particularly in cardiothoracic diseases.

Purpose of the Study:

  • To review the role of RELM signaling in the development and progression of various lung diseases.
  • To discuss the potential of RELMs as biomarkers for predicting lung disease risk and severity.

Main Methods:

  • Literature review of studies on RELM signaling in lung diseases.
  • Analysis of the involvement of RELMs in conditions such as pulmonary hypertension, asthma, COPD, fibrosis, cancers, and infections.

Main Results:

  • RELM signaling contributes to the initiation and progression of diverse lung pathologies.
  • RELMs demonstrate potential as predictive biomarkers for several respiratory and cardiovascular diseases.

Conclusions:

  • A deeper understanding of RELM signaling in pulmonary diseases can identify novel therapeutic targets.
  • Targeting RELM pathways may offer new strategies for treating inflammation, tissue remodeling, and fibrosis-related disorders.
Keywords:
FIZZ1HIMFRELMsinflammationlung

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

749
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

665

Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
895
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.0K
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
63.8K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.6K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.5K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K