Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

124
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
124
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.6K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.6K
Vaccinations01:51

Vaccinations

50.7K
Overview
50.7K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.4K
Development of Immunocompetence01:22

Development of Immunocompetence

639
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
639
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

312
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
312

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells.

Artificial cells, nanomedicine, and biotechnology·2025
Same author

Effect of Diet Compositions on Colony Strength Parameters, and the Enzymatic Activity of <i>Apis mellifera</i> L. During Floral Scarcity.

Insects·2025
Same author

Detection of the Early Sensitive Stage and Natural Resistance of Broad Bean (<i>Vicia faba</i> L.) Against Black Bean and Cowpea Aphids.

Insects·2025
Same author

Ethnomedicinal indices based ethno-veterinary plant profile of Yousaf Baba Hills, District Mohmand, Khyber Pakhtunkhwa, Pakistan.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Titanium Dioxide Nanoparticles-Induced Genotoxic Effects in Mosquito <i>Culex quinquefaciatus</i>.

Toxics·2025
Same author

Use of <i>Periplaneta americana</i> as a Soybean Meal Substitute: A Step towards Sustainable Transformative Poultry Feeds.

Insects·2024

Related Experiment Video

Updated: Dec 14, 2025

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
10:16

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles

Published on: August 17, 2022

3.7K

COVID-19 - Important considerations for developing and using a vaccine.

Inayat Ur Rahman1, Niaz Ali1, Farhana Ijaz1

  • 1Department of Botany, Hazara University , Mansehra, Pakistan.

Human Vaccines & Immunotherapeutics
|July 23, 2020
PubMed
Summary

The COVID-19 pandemic, caused by SARS-CoV-2, necessitates global cooperation for vaccine development and standardized clinical evaluations. Preventive measures like quarantine remain crucial in the absence of effective therapies or vaccines.

Keywords:
COVID-19CoronavirusSARS-CoV-2global pandemicvaccine

More Related Videos

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.9K
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
12:09

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

43.3K

Related Experiment Videos

Last Updated: Dec 14, 2025

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
10:16

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles

Published on: August 17, 2022

3.7K
Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.9K
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
12:09

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

43.3K

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • The emergence of SARS-CoV-2 has led to a global pandemic, straining healthcare systems worldwide.
  • Rapid spread of COVID-19 highlights the need for effective interventions and global response coordination.
  • Current preventive measures include lockdowns and social distancing, but a vaccine or therapy is critically needed.

Purpose of the Study:

  • To review the current status of COVID-19 vaccine development and clinical evaluation protocols.
  • To emphasize the importance of standardized protocols for safeguarding human subjects in vaccine trials.
  • To discuss the role of preventive measures in managing the pandemic.

Main Methods:

  • Review of current research on SARS-CoV-2 monoclonal antibodies.
  • Analysis of the necessity for standardized clinical trial protocols for COVID-19 vaccines.
  • Assessment of existing public health interventions for pandemic control.

Main Results:

  • Research is progressing in identifying monoclonal antibodies from recovered patients, potentially aiding vaccine design.
  • No definitive clinical data currently supports the efficacy of any candidate COVID-19 vaccine.
  • Standardized clinical evaluation protocols are essential for ensuring vaccine safety and efficacy.

Conclusions:

  • Development of effective COVID-19 vaccines and therapies is a global priority.
  • Strict adherence to standardized clinical evaluation protocols is paramount for human safety.
  • Quarantine and social distancing remain vital in mitigating pandemic spread until vaccines or therapies are available.