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Lipid-based Nanocarriers for Cancer and Tumor Treatment
Mohammed Tahir Ansari1, Thiya Anissa Ramlan2, Nurul Nadia Jamaluddin2
1School of Pharmacy University of Nottingham Malaysia, Semenyih, -43500, Selangor, Malaysia.
Abstract:
Cancer and tumor have been major reasons for numerous deaths in this century across the world. Many strategies have been designed to treat, diagnose, or prevent cancer. The success of chemotherapy largely depends on drug targeting. The advent of nanotechnology has vastly improved drug delivery for targeting and diagnosis. Nevertheless, the accuracy of drug targeting with polymeric nanoparticles has always been questionable. The polymeric nanoparticles synthesized from varieties of lipid-based compounds or combined with vectors, such as liposomes, ethosomes, and transfersomes, may allow the drug to overcome the issue of resistance to drug absorption in biological membranes. The combined effects of lipid-based nanocarriers are known to improve the efficacy and accuracy of polymeric nanoparticles. The present review explores the application of lipid based nanocarriers in the treatment and diagnosis of cancer A special focus is given to the use of lipid-based nanocarriers in the treatment, diagnosis, and mitigation of cancer located in blood, brain, lung, and colon. The treatment of these cancers has always been questionable as the chances of relapse are very high. The review encompasses the use of lipid-based nanocarriers in targeting tissue-specific cancer cells.
Insights
Lipid-based nanocarriers enhance polymeric nanoparticle drug delivery for improved cancer treatment and diagnosis. These nanocarriers target specific cancer cells, addressing challenges in chemotherapy and reducing relapse rates.
Area of Science:
- Nanomedicine
- Oncology
- Biotechnology
Background:
- Cancer remains a leading cause of global mortality, necessitating advanced therapeutic strategies.
- Chemotherapy's efficacy hinges on precise drug targeting, an area where polymeric nanoparticles show limitations.
- Nanotechnology offers improved drug delivery systems for cancer diagnosis and treatment.
Purpose of the Study:
- To review the application of lipid-based nanocarriers in cancer treatment and diagnosis.
- To highlight the role of lipid-based nanocarriers in overcoming drug resistance and improving polymeric nanoparticle accuracy.
- To focus on the use of these nanocarriers for blood, brain, lung, and colon cancers.
Main Methods:
- Review of existing literature on lipid-based nanocarriers in cancer therapy.
- Analysis of how lipid-based nanocarriers, including liposomes, ethosomes, and transfersomes, enhance drug delivery.
- Exploration of tissue-specific targeting capabilities of these nanocarriers.
Main Results:
- Lipid-based nanocarriers improve the efficacy and accuracy of polymeric nanoparticles in drug delivery.
- These systems can help overcome biological membrane resistance, enhancing drug absorption.
- Demonstrated potential in targeting specific cancer cells in various organs.
Conclusions:
- Lipid-based nanocarriers represent a promising advancement in cancer nanomedicine.
- Their application can improve treatment outcomes and diagnostic accuracy for challenging cancers.
- Further research into these targeted delivery systems is warranted for clinical translation.
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