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Overrunning in clinical trials: some thoughts from a methodological review

Ileana Baldi1, Danila Azzolina1,2, Nicola Soriani1

  • 1Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Loredan 18, 35121, Padova, Italy.

Trials
|July 23, 2020
PubMed
Summary

Overrunning data in sequential trials can alter early study conclusions. Choosing conservative methods for including this extra data depends on trial design and endpoint type.

Keywords:
Combining p valuesDeletion methodOverrunningRepeated confidence interval

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