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Updated: Dec 14, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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The CDK Inhibitor SIAMESE Targets Both CDKA;1 and CDKB1 Complexes to Establish Endoreplication in Trichomes

Kai Wang1, Ruth W Ndathe1, Narender Kumar1

  • 1Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, 70803.

Plant Physiology
|July 23, 2020
PubMed
Summary

The SIAMESE (SIM) protein in Arabidopsis promotes DNA replication without cell division by inhibiting cyclin-dependent kinase (CDK) complexes. This study reveals SIM targets both CDKA;1 and CDKB1, crucial for plant development.

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