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Updated: Dec 14, 2025

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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Redox priming promotes Aurora A activation during mitosis

Daniel C Lim1, Vladimir Joukov2, T Justin Rettenmaier3,4

  • 1MIT Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. danlim@mit.edu myaffe@mit.edu.

Science Signaling
|July 23, 2020
PubMed
Summary

Redox changes during mitosis regulate Aurora A kinase activity through cysteine modifications. This study reveals how these modifications impact kinase function and offers insights for developing targeted Aurora A inhibitors.

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