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Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial

Lauren Ledingham1,2, Curtis Tatsuoka3,4, Nori Minich3,5

  • 1Case Western Reserve University, Cleveland, OH, USA. lxl617@case.edu.

Journal of Perinatology : Official Journal of the California Perinatal Association
|July 23, 2020
PubMed

Insights

Caregiver missed work is a significant burden for black infants with prematurity-associated wheezing. Factors like vitamin D, recurrent wheeze, and other young children in the home influenced this impact.

Area of Science:

  • Neonatal Health
  • Public Health
  • Pediatric Respiratory Medicine

Background:

  • Prematurity-associated wheezing poses a significant health challenge for infants.
  • Caregiver work absence due to infant illness impacts families and the economy.
  • Understanding factors influencing missed work is crucial for targeted support.

Purpose of the Study:

  • To quantify the burden of caregiver missed work in black infants with prematurity-associated wheezing.
  • To identify factors associated with caregiver time off for infant care.
  • To highlight the socioeconomic impact of wheezing in premature infants.

Main Methods:

  • Analysis of data from the D-Wheeze trial (NCT01601847).
  • Inclusion of black infants born between 28-0/7 and 36-6/7 weeks' gestational age.
  • Primary outcome measured: caregiver missed work in the infant's first year.

Main Results:

  • Over half (53.1%) of infants had caregivers who reported missed work.
  • Vitamin D supplementation was associated with reduced missed work (OR 0.52).
  • Recurrent wheeze increased missed work (OR 2.26), while younger siblings decreased it (OR 0.45).

Conclusions:

  • Prematurity-associated wheezing in black infants leads to a substantial caregiver missed work burden.
  • This highlights the significant impact of prematurity-associated respiratory issues on families.
  • Further research and support systems are needed to mitigate these socioeconomic consequences.
Abstract

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