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A brand-new cardiorenal syndrome in the COVID-19  setting

Mugurel Apetrii1,2, Stefana Enache3, Dimitrie Siriopol1,2

  • 1Nephrology Clinic, Dialysis and Renal Transplant Center, "C.I. PARHON" University Hospital, Iasi, Romania.

Clinical Kidney Journal
|July 23, 2020
PubMed

Insights

Coronaviruses, including COVID-19, can affect the heart and kidneys, not just the lungs. The virus uses the ACE2 receptor, which is present in the heart, to cause cardiovascular issues.

Area of Science:

  • Virology
  • Cardiology
  • Infectious Diseases

Background:

  • Coronaviruses are significant pathogens causing respiratory infections in adults.
  • The COVID-19 pandemic, caused by SARS-CoV-2, primarily affects the lungs.
  • Emerging data link SARS-CoV-2 to cardiovascular complications.

Purpose of the Study:

  • To investigate the link between coronavirus infections and cardiovascular system impact.
  • To understand the role of ACE2 in SARS-CoV-2-related cardiovascular manifestations.

Main Methods:

  • Review of existing literature on coronaviruses and COVID-19.
  • Analysis of studies documenting SARS-CoV-2 interactions with ACE2.
  • Examination of reported cardiovascular and renal complications in COVID-19 patients.

Main Results:

  • Coronaviruses cause significant respiratory tract infections in adults.
  • COVID-19 has been associated with myocarditis, myocardial infarction, heart failure exacerbation, and acute kidney injury.
  • SARS-CoV-2 utilizes the ACE2 receptor for cellular entry, and ACE2 is expressed in cardiac tissue.

Conclusions:

  • Coronaviruses, particularly SARS-CoV-2, pose a threat beyond the respiratory system, affecting the cardiovascular system.
  • The expression of ACE2 in the heart provides a molecular mechanism for viral-induced cardiac pathology.
  • Further research is warranted to fully elucidate the cardiovascular sequelae of COVID-19.

Keywords:
ACE2CKDCOVID-19cardiorenal syndromemyocardial injury

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