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Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study

Daqing Hong1, Lin Long2, Amanda Y Wang3,4,5

  • 1Renal Department and Nephrology Institute, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Clinical Kidney Journal
|July 23, 2020
PubMed

Insights

Proteinuria and hematuria are common in COVID-19 patients, particularly severe cases. These urinary findings can help predict severe disease progression in coronavirus disease 2019 (COVID-19) infections.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) is a global pandemic impacting millions.
  • Previous studies indicated frequent kidney injury, proteinuria, and hematuria in severe COVID-19 cases.
  • The prevalence of kidney issues in milder COVID-19 cases remained largely unknown.

Purpose of the Study:

  • To investigate the occurrence and significance of kidney injury markers in COVID-19 patients.
  • To determine the association between proteinuria, hematuria, and disease severity.
  • To assess the predictive value of urinary abnormalities for severe COVID-19.

Main Methods:

  • Retrospective analysis of 168 COVID-19 patients from two cohorts in Sichuan Province.
  • Collection of baseline characteristics and laboratory data, including renal function, proteinuria, and dipstick hematuria.
  • Short-term follow-up for a subgroup to assess renal impairment outcomes.

Main Results:

  • Proteinuria and hematuria were observed in 18.4% and 17.4% of patients, respectively; acute kidney injury (AKI) was rare.
  • Severe or critical COVID-19 was significantly associated with higher risks of proteinuria and hematuria.
  • Proteinuria and hematuria, individually or combined, were significant predictors of severe or critical COVID-19.

Conclusions:

  • Proteinuria and dipstick hematuria are frequent findings in COVID-19 patients.
  • These urinary abnormalities are particularly prevalent in severe and critical cases.
  • Urinary findings can serve as important indicators for predicting COVID-19 severity.
Abstract

Keywords:
COVID-19acute kidney injury

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