Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Higher 25(OH)D Levels at Admission Predict a Favorable Disease Evolution in Moderate-to-Severe COVID-19 Patients.

International journal of molecular sciences·2026
Same author

Decellularized Extracellular Matrix/Gellan Gum Hydrogels Enriched with Spermine for Cardiac Models.

Gels (Basel, Switzerland)·2026
Same author

Potential phosphorylation of Liprin-α1 at threonine 701 regulates integrin-mediated cell motility.

PloS one·2025
Same author

Use of Hydrogels in Regenerative Medicine: Focus on Mechanical Properties.

International journal of molecular sciences·2024
Same author

Focal Adhesion's Role in Cardiomyocytes Function: From Cardiomyogenesis to Mechanotransduction.

Cells·2024
Same author

Characterisation of Matrix-Bound Nanovesicles (MBVs) Isolated from Decellularised Bovine Pericardium: New Frontiers in Regenerative Medicine.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Dec 14, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

11.7K

Natural hydrogels R&D process: technical and regulatory aspects for industrial implementation.

Marta Calvo Catoira1,2, Javier González-Payo3, Luca Fusaro2,4

  • 1Center for Translational Research on Autoimmune & Allergic Diseases-CAAD, 28100, Novara, Italy.

Journal of Materials Science. Materials in Medicine
|July 23, 2020
PubMed
Summary

Scaling up hydrogel therapies requires careful consideration of technology transfer, especially for 3D printing applications. This review examines key factors, including decellularized tissues, process parameters, and legal aspects under new EU regulations.

More Related Videos

Author Spotlight: A Novel Approach for Embedding Cell-Free Protein Synthesis Reactions in Hydrogels
06:38

Author Spotlight: A Novel Approach for Embedding Cell-Free Protein Synthesis Reactions in Hydrogels

Published on: June 23, 2023

1.6K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K

Related Experiment Videos

Last Updated: Dec 14, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

11.7K
Author Spotlight: A Novel Approach for Embedding Cell-Free Protein Synthesis Reactions in Hydrogels
06:38

Author Spotlight: A Novel Approach for Embedding Cell-Free Protein Synthesis Reactions in Hydrogels

Published on: June 23, 2023

1.6K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Biotechnology

Background:

  • Hydrogel therapies are increasingly used in clinical treatments, necessitating industrial scale-up.
  • Technology transfer and process scaling are critical for implementing new hydrogel technologies.
  • Decellularized tissues offer superior biological properties for bioinks but pose scale-up challenges.

Purpose of the Study:

  • To review critical aspects of scaling up natural hydrogels for industrial applications.
  • To address challenges in technology transfer and process scale-up for hydrogel therapies.
  • To consider the impact of regulatory frameworks, such as EU Regulation 2017/745, on hydrogel scale-up.

Main Methods:

  • Literature review of technology transfer and scale-up processes for hydrogels.
  • Analysis of factors influencing hydrogel industrialization, including bioink sources and process parameters.
  • Examination of legal and regulatory considerations for biomedical devices.

Main Results:

  • Scaling up hydrogel production involves challenges in areas like 3D printing and the use of decellularized tissues.
  • Controlling chemical and physical parameters during gelling is essential for process success.
  • Legal and regulatory compliance, particularly with Regulation (EU) 2017/745, is vital for market implementation.

Conclusions:

  • Successful scale-up of natural hydrogels requires a holistic approach, balancing technical, biological, and regulatory factors.
  • Optimizing costs for raw materials and manufacturing is crucial for economic viability.
  • Addressing these multifaceted aspects will facilitate the broader clinical adoption of advanced hydrogel therapies.