Related Experiment Video
Updated: Dec 14, 2025
Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Successful Matched Related Bone Marrow Transplantation in a Patient with Autosomal Dominant Interferon Gamma Receptor
Christa S Zerbe1, Dimana Dimitrova2, Juan J Gea-Banacloche3
1Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. zerbech@niaid.nih.gov.
Abstract:
This is a report of a successful bone marrow transplant in an IFN-γR1 patient with progressive mycobacterial infection.
Purpose:
Hematopoietic cell transplant in patients with interferon gamma receptor deficiencies has been fraught with challenges, not the least of which is failure of engraftment and infectious complications.
Methods:
This is a report of a successful hematopoietic cell transplant in an actively infected patient of advanced age.
Results:
This case report shows successful engraftment and resolution of infection posttransplant using a matched related donor in a single institution.
Conclusion:
A successful curative HCT despite persistent, disseminated, nontuberculous mycobacterial infection in a patient with AD-IFNγR1 suggests that this approach, while difficult, may be useful in other patients with otherwise refractory disease.
