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Identification of Post-translational Modifications of Plant Protein Complexes
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TLPdb: A Resource for Thaumatin-Like Proteins
Chandana Thimme Gowda1, Siva Naga Suresh Purama2, Rajagopal Kammara3,4
1Department of Protein Chemistry and Technology, CFTRI, Mysore, India.
The Protein Journal
|July 23, 2020
Summary
Thaumatin-like proteins (TLPs) are crucial for antifungal activity. A new database, TLPdb, offers access to TLP sequences and structures, aiding research into fungal resistance in crops and human health.
Area of Science:
- Biochemistry
- Bioinformatics
- Plant Science
Background:
- Antifungal proteins and peptides are vital for crop protection and human health.
- Thaumatin-like proteins (TLPs) exhibit antifungal properties, distinct from sweet-tasting thaumatins.
- Understanding TLP amino acid residues is key to their antifungal mechanisms.
Purpose of the Study:
- To develop a comprehensive, freely accessible database of thaumatin-like proteins (TLPs).
- To provide insights into the mechanistic aspects of TLP antifungal activity.
- To facilitate the development of fungal-resistant crops and understand TLP evolution.
Main Methods:
- Curated and compiled validated TLP protein sequences from diverse organisms (plant, fungal, animal).
- Included protein sequences, structures, and amino acid compositions.
- Developed a publicly accessible online database (TLPdb).
Main Results:
- Established TLPdb, a centralized resource for TLP information.
- The database contains validated TLP sequences, structures, and amino acid compositions.
- TLPdb serves as a bioinformatics tool for TLP research.
Conclusions:
- TLPdb provides valuable data for understanding TLP mechanisms and evolution.
- The database can aid in developing strategies for fungal resistance in crops.
- Accessible TLP data supports advancements in antifungal research and applications.
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