Related Experiment Video

Updated: Dec 14, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.9K

The biological function and the regulatory roles of wild-type p53-induced phosphatase 1 in immune system

Lu Shi1, Qianchuan Tian1,2, Chang Feng1,2

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

International Reviews of Immunology
|July 23, 2020
PubMed

Insights

Wild-type p53-induced phosphatase 1 (WIP1) is a key regulator in cell processes and immune responses. This phosphatase shows potential as a therapeutic target for cancers and immune diseases like allergic asthma.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine specific protein phosphatase belonging to the protein phosphatase 2C (PP2C) family.
  • WIP1 dephosphorylates numerous signaling molecules, regulating critical cellular processes including DNA damage repair, proliferation, differentiation, apoptosis, and senescence.
  • WIP1 functions as an oncogene, negatively regulating p53 and promoting tumor development, and is implicated in aging and neurological and immune diseases.

Purpose of the Study:

  • To summarize the expression patterns, biological functions, and target molecules/pathways of WIP1.
  • To discuss recent advances in understanding WIP1's regulatory effects on the immune system.
  • To explore WIP1 as a potential therapeutic target for cancers and immune diseases.

Main Methods:

  • Literature review and summary of existing research on WIP1.
  • Analysis of WIP1's role in various cellular processes and disease states.
  • Focus on recent findings regarding WIP1's impact on immune cell differentiation and function.

Main Results:

  • WIP1 plays significant regulatory roles in fundamental cell processes and is linked to aging and various diseases.
  • Recent studies highlight WIP1's critical involvement in the differentiation and function of key immune cells like T cells, neutrophils, and macrophages.
  • WIP1's oncogenic activity and its role in immune regulation are well-documented.

Conclusions:

  • WIP1 is a multifaceted protein with significant implications in both cancer and immune system regulation.
  • The study underscores WIP1's potential as a therapeutic target for treating malignancies and immune-related disorders such as allergic asthma.
  • Further research into WIP1's specific pathways may unlock novel treatment strategies.
Keywords:
Gene expressionTh9 cellsWIP1immunityneutrophilssignaling pathways

More Related Videos

Purification of Ubiquitinated p53 Proteins from Mammalian Cells10:55

Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

2.5K
Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

6.5K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.0K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.0K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
2.9K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.8K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.9K